Protective action of Cuminum cyminum against cisplatin induced nephrotoxicity in rats
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Date
2012
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Volume Title
Publisher
Sebha University
Abstract
Objective: The nephroprotective activity of aqueous extract of Cuminum cyminum (AEC) was evaluated on cisplatin (CP) induced nephrotoxicity in rats.
Methods: The rats were divided into four groups of six animals each. Group I treated with normal saline (2 ml/kg, p.o.). The group II treated with cisplatin (12 mg/kg i.p), group III and IV were treated with AEC (100 & 200 m/kg, p.o.). for 10 days, After 24 hrs of last dose of AEC treatment, blood was collected and serum was separated and subjected to serum creatinine and urea analysis. The kidneys were removed and homogenate for estimation of lipid peroxidation, reduced glutathione, superoxide dismutase (SOD) and catalase.
Results: CP treated rats caused nephrotoxicity as evidenced by marked elevation of serum urea, creatinine and lipid peroxidation levels and decreased levels of glutathione, SOD, catalase. Treatment of rats with different doses of AEC (100 and 200 mg/kg) significantly (P<0.001) altered serum urea, creatinine enzymes, lipid peroxidation and antioxidant levels to near normal against cisplatin treated rats. The results shown AEC produce nephroprotective effect on dose dependent manner.
Conclusion: The Cuminum cyminum showed the protective effect against CP induced nephrotoxicity in rats.
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Keywords
Cisplatin, Nephrotoxicity, Antioxidants, Cuminum cyminum