Facile Synthesis of Thiazolidin-4-one Derivatives Incorporating Indole Moiety
| dc.contributor.author | A. Altamamy, Hussein. | |
| dc.date.accessioned | 2017-11-27T07:51:25Z | |
| dc.date.available | 2017-11-27T07:51:25Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Condensation of ethyl 3-formyl-1H-indole-2-carboxylate (1) with thiosemicarbazide in ethanol gave ethyl 3-(thiosemicarbazidomethyl)-1H-indole-2-carboxylate (2). Treatment of 2 with chloroacetic acid afforded the thiazolidin-4-one derivative 3. Condensation of 3 with aromatic aldehydes gave the corresponding arylidene derivatives 4a-c. Cyclization of 4a-c with hydroxylamine hydrochloride in the presence of sodium acetate yielded thiazolidino[4,5-c]isoxazoline derivatives 5a-c. The structure of the synthesized compounds were confirmed using elemental and spectroscopic analysis. | ar |
| dc.identifier.uri | https://repository.sebhau.edu.ly/handle/1/155 | |
| dc.language.iso | en | ar |
| dc.publisher | Sebha University | ar |
| dc.title | Facile Synthesis of Thiazolidin-4-one Derivatives Incorporating Indole Moiety | ar |
| dc.type | Article | ar |