Effect of fenugreek seeds and cinnamon bark aqueous extracts on liver and kidney functions in male diabetic rats

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Sebha University
Trigonella foenum-graecum (Fenugreek) seeds and Cinnamomum zeylanicum (Cinnamon) bark have long been utilized for culinary purposes prior to being recognized as a hypoglycemic agents. Here we tested the hypothesis that administration of fenugreek seeds and cinnamon bark modulates the adverse effects of diabetes on blood glucose, liver enzymes and kidney functions of diabetes induced by alloxan in male rats by using their aqueous extracts. Induction of diabetes significantly increased the blood glucose associated with a significant depression in the activity of liver enzymes and kidney functions. The animals is divided into 6 groups each contains 6 rats: normal group, diabetic group, two diabetic groups treated separately with low dose and high dose of aqueous fenugreek extract and two diabetic groups treated separately with low dose and high dose of aqueous cinnamon extract. Compared with untreated diabetic group, there were a significant decrease in F.B.G., ALT, AST, ALP, Urea and Creatinine levels in treated diabetic rats after administration with extracts and that effects were depend on doses, and also cinnamon had better effects than fenugreek.
Fenugreek, Cinnamon, Extracts, Alloxan, Diabetes, Liver enzymes, Kidney functions. Introduction: Diabetes Mellitus (DM) is one of major metabolic disorders, it's characterized by high blood glucose levels(1). The number of people living with diabetes is expected to rise from 366 million in 2011 to 552 million by 2030. 80% of people with diabetes live in low and middle income countries(2). It's generally considered that hyperglycemia is the major factor in the pathogenesis of diabetic complications(3). Hyperglycemia and the effects of diabetogenic agent Alloxan in experimental diabetes increase the generation of free radicals that may lead to liver cells damage(4),(5), and that causes to impairment of liver function(6). Impairment of kidney function is a prominent feature of diabetes, Over time diabetic nephropathy will develop(3). Medicinal plants play an important role in the management of diabetes especially in developing countries where resources are meager(7),(8). Presently, there is an increased demand to use natural products with antidiabetic activity(9) due to the secondary failure rates and side effects associated with the use of insulin and oral hypoglycemic agents(9),(6). Trigonella foenum-graecum (Fenugreek)