The relation between -synuclein and cancer
| dc.contributor.author | Salem A. Sultan, Nuri H. Awayn | |
| dc.date.accessioned | 2017-11-26T11:18:16Z | |
| dc.date.available | 2017-11-26T11:18:16Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | The -synuclein gene is a member of the human synuclein genes (, and ). The sequence data of the human synuclein genes showed that -synuclein is similar by 55.9% of -synuclein and 54.3% of -synuclein sequence. The -synuclein gene sequence is highly similar to breast cancer-specific gene one (BCSG1). -synuclein was found to be expressed at high levels in aging cerebral cortex, and also in breast tumours. -synuclein or (BCSG1) was found highly increased in infiltrating breast cancers compared with normal breast tissues and benign cancers. Here, we investigate the expression of -synuclein gene in a number of different cancer cell lines. These cell lines were derived from normal breast (HBL 100), hepatocarcinoma (SK-HEP1), vulval epidermoid carcinoma (A431), human metastatic breast cancer (MDA-MB231, T47D, and MCF-7), and human ovarian cancer (PEO1). Our data were confirmed the differential expression of the -synuclein gene in breast and ovarian cancer cell lines. Furthermore, our data did not show the reported two polymorphisms in the coding region of the -synuclein gene (G C at position 243 and T A at position 377). All those together suggests that the -synuclein gene may involved in the aetiology of the breast and ovarian cancers. | ar |
| dc.identifier.uri | https://repository.sebhau.edu.ly/handle/1/137 | |
| dc.language.iso | en | ar |
| dc.publisher | Sebha University | ar |
| dc.subject | Synuclein, ovarian cancer, Breast cancer | ar |
| dc.title | The relation between -synuclein and cancer | ar |
| dc.type | Article | ar |