EQUILIBRIUM STUDIES OF COMPLEXES WITH METAL IONS AND POTENTIOMETRIC AND CONDUCTOMETRIC DETERMINATION OF NALIDIXIC ACID IN TABLETS
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Sebha University
Abstract
Ten metal ions viz, Fe(III), Cr(III), La(II), Sn(II), Co(II), Ba(II), Pd(II), Ti(II),
Sr(II) and Zr(II), were selected to elucidate the interaction of these metal ions with
nalidixic acid(NAL) using potentiometric and conductometric methods. The
ionization constant of the ligand and stability constants of the complexes formed have
been tabulated at 25±1.0Cº and 0.01 M ionic strength of NaCl in 25 %( v/v) aqueousethanol
solution.
Complexes of 1:1, 1:2 and/or 1:3 metals to ligand ratios are formed depending
on the nature of the ligand or metal ions. As well as, the stoichiometry of complexes
confirmed by conductometric method. Also simple, precise, rapid and low-cost
potentiometric and conductometric methods for nalidixic acid determination in pure
form and tablets are proposed. Nalidixic acid present in tablets containing known
quantity of drug were potentiometrically titrated by 0.1M of NaOH using a combined
glass pH electrode.
The detection limit was 2.20 mg /25ml. The calibration graph is linear in the
range of 0.23– 2.55 mg/25ml. The correlation coefficient of determination (r) comes
out to be 0.9972. The standard deviation (SD) was 2.77. No interferences were
observed in the presence of common components of the tablets. The percentage
recoveries of nalidixic acid in tablet dosage formulations by potentiometric and
conductometric methods were (95.8-98.68) %, with standard deviations (SD) were
(within (0.18–0.4) (n=5